ANTITHROMBOTIC THERAPY IN ACUTE CORONARY SYNDROME: CURRENT RECOMMENDATIONS AND PRACTICAL ASPECTS

Abstract

The article presents a systematic review of modern approaches to antithrombotic therapy in acute coronary syndrome, taking into account current international and Russian clinical recommendations, as well as the results of a single-center observational study conducted on the example of a sample of patients treated in a multidisciplinary clinic in Novosibirsk.

The structure of prescribed antithrombotic therapy, the degree of compliance of therapeutic tactics with current recommendations, and the relationship of decisions made with immediate and long-term clinical outcomes are analyzed.

It is shown that the basic concept of modern therapy for acute coronary syndrome is based on the combined use of antiplatelet and anticoagulant drugs, individualization of the duration and intensity of therapy, taking into account ischemic and hemorrhagic risk, and integration of an antithrombotic strategy with reperfusion interventions.

Practical aspects of implementing the recommendations in the Russian context are discussed, including organizational and pharmacoeconomic constraints, routing features, and problems of adherence to therapy. Conclusions on the directions of optimization of antithrombotic therapy in acute coronary syndrome at the level of clinical practice are formulated.