EFFECT OF FIPRONIL ON THE PHYSIOLOGICAL STATUS OF FEMALE RATS

Abstract

Fipronil was an extensively used insecticide for crop protection in the world wide from the last decade due to its low soil persistence and insecticidal activity at low application. The present study was designed to investigate the adverse effects of sub-acute exposure to Fipronil on biochemical blood profile and histological parameters in male rats according to the permissible limits of acceptable daily intake (ADI). The results hematological parameters indicated that red blood cells (RBCs) and Hemoglobin (H.b) decreased in all treated groups compared with the control. While PLT and white blood cells (WBCs) was significantly increased in all treated groups compared with the control. The toxicity of effects of nano-fipronil pesticides leads to higher levels of liver function parameters (AST, ALT and ALP) and kidney function (Blood urea and Creatinine and Uric acid) results demonstrated highly significant differences (P≤0.05) in all groups treated compared with the control. Nano-fipronil caused histopathological alterations in liver and kidney tissues of male rats.