FROM BLISTER TO DIAGNOSIS: CLINICOPATHOLOGICAL CORRELATION OF VESICOBULLOUS SKIN LESIONS.

Abstract

Introduction: Vesicobullous skin disorders are a diverse group of dermatological diseases characterized by vesicles and bullae involving the skin and mucosal surfaces These lesions often present with overlapping clinical features, making accurate diagnosis difficult without histopathological evaluation aim is to study the clinicopathological spectrum of vesicobullous skin lesions and assess the correlation between clinical and histopathological findings.

Materials and Methods: This retrospective study was carried out in the Department of Pathology over a period of one years. A total of 100 skin biopsies clinically diagnosed as vesicobullous lesions were analyzed. Clinical details and histopathological findings were reviewed and correlated.

Results: The majority of patients were between 31–50 years of age with female predominance. Pemphigus vulgaris was the most common vesicobullous lesion identified. Histopathology showed characteristic features such as suprabasal clefting in pemphigus vulgaris and subepidermal blistering in bullous pemphigoid. A high degree of clinicopathological agreement was observed.

Conclusion: Histopathological examination combined with clinical assessment plays a key role in the accurate diagnosis of vesicobullous lesions and helps in appropriate patient management.