THE INFLUENCE OF PERIODONTAL THERAPY ON THE LEVEL OF SYSTEMIC INFLAMMATORY MARKERS IN CARDIAC PATIENTS

Abstract

Given the proven role of low-grade chronic inflammation in the progression of atherosclerosis and cardiovascular disease, studying the effect of oral hygiene on markers of systemic inflammation appears clinically significant.

The study was conducted in the cardiology department of the Novosibirsk City Clinical Hospital No. 25 and included 110 patients with coronary heart disease and concomitant moderate to severe chronic generalized periodontitis. The study group (n=60) received standard cardiac therapy combined with comprehensive non-surgical periodontal care (professional hygiene, scaling and root smoothing, personal hygiene training, and antiseptic support). The control group (n=50) received only standard cardiac treatment and hygiene recommendations without active periodontal intervention.

Levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were determined at baseline and after six months. In the study group, a statistically significant decrease in CRP by an average of 33%, IL-6 by 27%, and TNF-α by 25% compared to baseline was observed, while no significant changes were observed in the control group.

These results indicate that the treatment of chronic infection and inflammation in the oral cavity in cardiac patients is accompanied by a reduction in the systemic inflammatory response and can be considered as an additional approach to secondary prevention of cardiovascular complications.