COMPARATIVE EVALUATION OF LFT IN PATIENTS WITH ALCOHOL CONSUMPTION CO-INFECTED WITH BLOOD BORNE VIRUSES

Abstract

This study aims to assess changes in liver enzyme levels among individuals with liver disease and compare them to healthy individuals to determine the severity and effects of HBV, HCV, HIV, and co-infections. A total of 1,012 serum samples were collected, including 512 from patients with liver disease and 500 from healthy individuals. These samples were screened for HBV, HCV, and HIV markers using ELISA tests. Liver function tests (LFTs) were conducted to measure levels of albumin, bilirubin (total, direct, and indirect), and enzymes such as serum alkaline phosphatase (SAP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transpeptidase. Statistical analysis was performed using one-way analysis of variance (ANOVA) to evaluate differences between the groups. A significant increase in liver enzyme levels was observed in HCV-affected patients, with pigmentation noted in those co-infected with HBV, HCV, and HIV. The statistical analysis revealed significant levels of total, direct, and indirect bilirubin, as well as SAP, among liver disease patients compared to healthy individuals. Notably, HCV-positive individuals who consumed alcohol exhibited higher liver enzyme and pigment levels. Additionally, alcohol consumers with HCV and HIV co-infections showed a greater elevation in liver enzymes than non-alcoholic HCV patients. The study indicates significantly elevated liver enzymes in HCV patients, particularly those with co-infections and alcohol consumption. Liver function tests are crucial for assessing disease severity, revealing notable differences between healthy and diseased individuals.