X.F. De la Rosa Reyna, H.M. Montoya, V.V. Castrellón, A.M.S. Rincón, M.P. Bracamonte, W.A. Vera
Published May 11, 2010
Genet. Mol. Res. 9 (2): 875-883 (2010)
DOI 10.4238/vol9-2gmr745

About the Authors
X.F. De la Rosa Reyna, H.M. Montoya, V.V. Castrellón, A.M.S. Rincón, M.P. Bracamonte, W.A. Vera

Corresponding author
X.F. De la Rosa Reyna
Email: xdelarosa@ipn.mx

ABSTRACT

The IGF1 gene (insulin-like growth factor 1) is a candidate gene for marker-assisted selection strategies. A single nucleotide polymorphism in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds. Here, we report its allelic frequencies in Charolais and Beefmaster breeds; we confirm its association with three growth traits: weaning weight, weaning weight adjusted to 210 days and preweaning weight gain in the Charolais breed. In addition, we designed a strategy to search these breeds for new polymorphisms in four coding regions of the gene. A C/A transversion was detected in intron 4, but it was not associated with the growth traits. A single nucleotide polymorphism (IGF1/SnaBI) is proposed as a selection marker for Mexican Charolais cattle; validation of its association with weaning weight, weaning weight adjusted to 210 days and preweaning weight gain, could complement the genetic evaluations of this breed through marker-assisted management strategies.

Key words: IGF1, SNP IGF1/SnaBI, Polymorphism, Charolais Beefmaster.