Polymorphisms in the IGF1 gene and their effect on growth traits in Mexican beef cattle

X.F. De la Rosa Reyna, H.M. Montoya, V.V. Castrellón, A.M.S. Rincón, M.P. Bracamonte, W.A. Vera
Published May 11, 2010
Genet. Mol. Res. 9 (2): 875-883 (2010)
DOI 10.4238/vol9-2gmr745

About the Authors
X.F. De la Rosa Reyna, H.M. Montoya, V.V. Castrellón, A.M.S. Rincón, M.P. Bracamonte, W.A. Vera

Corresponding author
X.F. De la Rosa Reyna
Email:
xdelarosa@ipn.mx

ABSTRACT

The IGF1 gene (insulin-like growth factor 1) is a candidate gene for marker-assisted selection strategies. A single nucleotide polymorphism in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds. Here, we report its allelic frequencies in Charolais and Beefmaster breeds; we confirm its association with three growth traits: weaning weight, weaning weight adjusted to 210 days and preweaning weight gain in the Charolais breed. In addition, we designed a strategy to search these breeds for new polymorphisms in four coding regions of the gene. A C/A transversion was detected in intron 4, but it was not associated with the growth traits. A single nucleotide polymorphism (IGF1/SnaBI) is proposed as a selection marker for Mexican Charolais cattle; validation of its association with weaning weight, weaning weight adjusted to 210 days and preweaning weight gain, could complement the genetic evaluations of this breed through marker-assisted management strategies.

Key words: IGF1, SNP IGF1/SnaBI, Polymorphism, Charolais Beefmaster.

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