M.S. Brassesco
Published: September 02, 2008
Genet. Mol. Res. 7 (3) : 782-790
DOI: https://doi.org/10.4238/vol7-3gmr486
Cite this Article:
M.S. Brassesco (2008). Leukemia/lymphoma-associated gene fusions in normal individuals. Genet. Mol. Res. 7(3): 782-790. https://doi.org/10.4238/vol7-3gmr486
About the Authors
M.S. Brassesco
Corresponding Author
M.S. Brassesco
Email: marsol@rge.fmrp.usp.br, solbrassesco@hotmail.com
ABSTRACT
Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence of these rearrangements indicates that such translocations can be generated in normal hematopoietic cells without apparent oncogenic consequences. This article reviews and discusses the data available in the literature.
Key words: Leukemia, gene fusions, genomic instability, lymphoma, healthy individuals.