I.R. Costa, R.C.P.C. Silva, A.B. Frare, C.T.X. Silva, B.M. Bordin, S.R. Souza, C.L. Ribeiro Júnior and K.K.V.O. Moura
Published: Published July 6, 2011
Genet. Mol. Res. 10 (3): 1364-1370
DOI: https://doi.org/10.4238/vol10-3gmr913

Cite this Article:
I.R. Costa, R.C.P.C. Silva, A.B. Frare, C.T.X. Silva, B.M. Bordin, S.R. Souza, C.L. Ribeiro Júnior and K.K.V.O. Moura (2011). Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil . Genet. Mol. Res. 10(3): 1364-1370. https://doi.org/10.4238/vol10-3gmr913

About the Authors:
I.R. Costa, R.C.P.C. Silva, A.B. Frare, C.T.X. Silva, B.M. Bordin, S.R. Souza, C.L. Ribeiro Júnior and K.K.V.O. Moura
Corresponding author: I.R. Costa
E-mail: iasmimribeirodacosta@gmail.com

ABSTRACT
We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.

Key words: Endometriosis, Progesterone receptor, PROGINS, PCR.