E. Armagan, M.L. Almacıoglu, T. Yakut, A. Köse, M. Karkucak, O. Köksal, O. Gorukmez
Published: March 19, 2013
Genet. Mol. Res. 12 (1) : 852-858
DOI: https://doi.org/10.4238/2013.March.19.1
Cite this Article:
E. Armagan, M.L. Almacıoglu, T. Yakut, A. Köse, M. Karkucak, O. Köksal, O. Gorukmez (2013). Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder. Genet. Mol. Res. 12(1): 852-858. https://doi.org/10.4238/2013.March.19.1
About the Authors
E. Armagan, M.L. Almacıoglu, T. Yakut, A. Köse, M. Karkucak, O. Köksal, O. Gorukmez
Corresponding Author
A. Köse
Email: ataberk76@yahoo.com.tr
ABSTRACT
Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.
Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.
Key words: COMT, Val158Met genotype, Conversion disorder.