Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population

S.F. Tee, T.J. Chow, P.Y. Tang and H.C. Loh
Published July 6, 2010
Genet. Mol. Res. 9 (3): 1274-1278 (2010)
DOI 10.4238/vol9-3gmr789

About the Authors
S.F. Tee, T.J. Chow, P.Y. Tang and H.C. Loh

Corresponding author:
H.C. Loh


The serotoninergic system has been implicated in the etiology of schizophrenia and other behavioral disorders. Association studies have focused on the tryptophan hydroxylase 2 gene (TPH2) and the 5-hydroxytryptamine receptor 2A gene (5-HTR2A). We genotyped two single-nucleotide polymorphisms, A1438G of 5-HTR2A and intronic rs1386494 of TPH2 in the Malay population, using a sample size of 289 schizophrenic patients and 130 healthy controls. We found a significant association of A1438G of 5-HTR2A with schizophrenia in Malays. On the other hand, TPH2 polymorphism was not associated with schizophrenia. This is the first genetic association study concerning schizophrenia in the Malay population.

Key words: Schizophrenia; Serotonin; 5-HTR2A; TPH2; Single-nucleotide polymorphism

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