General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis

Fabrício B.M. Arraes, Bruno Benoliel, Rafael T. Burtet,Patrícia L.N. Costa, Alexandro S. Galdino, Luanne H.A. Lima, Camila Marinho-Silva, Luciana Oliveira-Pereira, Pollyanna Pfrimer,Luciano Procópio-Silva, Viviane Castelo-Branco Reis, Maria Sueli S. Felipe
Published June 30, 2005
Genet. Mol. Res. 4 (2): 290-308 (2005)

About the Authors
Fabrício B.M. Arraes, Bruno Benoliel, Rafael T. Burtet,Patrícia L.N. Costa, Alexandro S. Galdino, Luanne H.A. Lima, Camila Marinho-Silva, Luciana Oliveira-Pereira, Pollyanna Pfrimer,Luciano Procópio-Silva, Viviane Castelo-Branco Reis, Maria Sueli S. Felipe

Corresponding author
M.S.S. Felipe
Email: msueli@unb.br

ABSTRACT

Annotation of the transcriptome of the dimorphic fungus Paracoccidioides brasiliensis has set the grounds for a global understanding of its metabolism in both mycelium and yeast forms. This fungus is able to use the main carbohydrate sources, including starch, and it can store reduced carbons in the form of glycogen and trehalose; these provide energy reserves that are relevant for metabolic adaptation, protection against stress and infectivity mechanisms. The glyoxylate cycle, which is also involved in pathogenicity, is present in this fungus. Classical pathways of lipid biosynthesis and degradation, including those of ketone body and sterol production, are well represented in the database of P. brasiliensis. It is able to synthesize de novo all nucleotides and amino acids, with the sole exception of asparagine, which was confirmed by the fungus growth in minimal medium. Sulfur metabolism, as well as the accessory synthetic pathways of vitamins and co-factors, are likely to exist in this fungus.

Key words: Paracoccidioides brasiliensis, Metabolism, Transcriptome, Expressed sequence tags, Paracoccidioidomycosis, Dimorphic fungus

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