Risk factor

A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region

H. C. Wang, Liu, C., He, H. Y., and Wang, M. X., “A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region”, vol. 14, pp. 5862-5869, 2015.

The incidence of urinary calculus (UC) is very high in Uyghur children in the Kashi region of Xinjiang, China, which seriously affects the growth and life quality of these children. This study was aimed at investigating the risk factors of UC in Uyghur children in Kashi region. One hundred fifteen Uyghur children (age

Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population

L. T. Zhang, Wei, F. J., Zhao, Y., Zhang, Z., Dong, W. T., Jin, Z. N., Gao, F., Gao, N. N., Cai, X. W., Li, N. X., Wei, W., Xiao, F. S., Yue, S. Y., Zhang, J. N., Yang, S. Y., Li, W. D., and Yang, X. Y., “Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population”, vol. 14, pp. 6865-6878, 2015.

Few studies have examined the genes related to risk fac­tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the association of IA and IA rup­ture with risk factors. Twenty-eight single nucleotide polymorphisms (SNPs) in 22 genes were genotyped for the patient and control groups.

Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women

Y. P. Liu, Zhao, D. W., Wang, W. M., Wang, B. J., Zhang, Y., and Li, Z. G., “Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women”, vol. 13, pp. 3560-3566, 2014.

Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442 age-matched healthy controls. The BMD at the femoral neck hip, lumbar spine (L2-4), and total hip were assessed by Norland XR-46 dual-energy X-ray absorptiometry.

Association of the g.19074G>A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women

Y. D. Zhang, Zhang, Z., Zhou, N. F., Jia, W. T., Cheng, X. G., and Wei, X. J., “Association of the g.19074G>A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women”, vol. 13, pp. 6646-6652, 2014.

Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to investigate the g.19074G>A genetic variant. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA) in 856 unrelated Chinese postmenopausal women.

The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population

H. Wang, Zhao, Y., Ma, J., Zhang, G., Mu, Y., Qi, G., Fang, Z., Wang, L., Fan, Q., and Ma, Z., “The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population”, vol. 12. pp. 67-73, 2013.

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms previously reported in Caucasians, that is, rs401681 at 5p15.33 and rs8034191 at 15q25, in a case-control study with 492 LC cases and 486 cancer-free controls in a Chinese population.

Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women

G. L. Flores-Ramos, A. De Dios, E. -, Puebla-Pérez, A. M., Figuera-Villanueva, L. E., Ramos-Silva, A., Ramírez-Patiño, R., Delgado-Saucedo, J. I., Salas-González, E., Zúñiga-González, G. M., Alonzo-Rojo, A., Gutiérrez-Hurtado, I., and Gallegos-Arreola, M. P., “Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women”, vol. 12, pp. 5680-5693, 2013.

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with those of 465 Mexican women with breast cancer. The observed genotype frequencies for controls and breast cancer patients were 1 and 14% for AA, 13 and 21% for GA, and 86 and 65% for GG, respectively.

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