Polymorphism

Polymorphic microsatellite loci for the razor clam, Sinonovacula constricta

H. - T. Ma, Jiang, H. - B., Liu, X. - Q., Wu, X. - P., and Wei, X. - M., Polymorphic microsatellite loci for the razor clam, Sinonovacula constricta, vol. 14, pp. 145-148, 2015.

The razor clam, Sinonovacula constricta, is an important commercial bivalve and a popular mollusca food in China. Twelve polymorphic microsatellite markers were isolated from the razor clam using a partial genomic library enriched for tandem repeat sequences of (CA)16, (GA)16. Polymorphisms of these loci were evaluated in a wild population of 30 individuals. The allele number of these polymorphic markers ranged from 5-15 per locus with an average of 9.333. Observed and expected heterozygosity values ranged from 0.192-1.000 and 0.219-0.906.

Association of liver X receptor α (LXRα) gene polymorphism and ischemic stroke

H. X. Wang, Zhang, K., Zhao, L., Tang, J. W., Gao, L. Y., and Wei, Z. P., Association of liver X receptor α (LXRα) gene polymorphism and ischemic stroke, vol. 14, pp. 118-122, 2015.

We examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy control subjects. The chi-square test was used to analyze the genotype distribution between the 2 groups.

TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis

H. G. Wang, Yang, J., Han, H., Xu, F., Bian, Y., Zhang, H., and Wang, J. L., TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis, vol. 14, pp. 563-573, 2015.

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE).

Molecular characterization, tissue expression, and polymorphism analysis of liver-type fatty acid binding protein in Landes geese

Z. Song, Shao, D., Sun, X. X., Niu, J. W., and Gong, D. Q., Molecular characterization, tissue expression, and polymorphism analysis of liver-type fatty acid binding protein in Landes geese, vol. 14, pp. 389-399, 2015.

Liver weight is an important economic trait in the fatty goose liver industry. Liver-type fatty acid binding protein (L-FABP) is involved in the formation and metabolism of fatty acids. Thus, we hypothesized that sequence polymorphisms in L-FABP were associated with fatty liver weight in goose. We first isolated, sequenced, and characterized the goose L-FABP gene, which had not been previously reported. The goose L-FABP gene was 2490 bp and included 4 exons coding for a 126-amino acid protein.

Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer’s disease in the Chinese population: a meta-analysis of case-control studies

L. Yang, Zhou, H. - H., Ye, Y. - F., Fan, X. - W., Wang, Y. - J., and Meng, Y., Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer’s disease in the Chinese population: a meta-analysis of case-control studies, vol. 14, pp. 1017-1024, 2015.

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to obtain summary estimates regarding their associations with AD.

Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis

W. Zheng, Wang, L., Su, X., and Hu, X. F., Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis, vol. 14, pp. 989-999, 2015.

In this study, we evaluated the associations between the V4 (rs2787094 G>C) polymorphism in a disintegrin and metalloproteinase domain 33 (ADAM33) gene and asthma risk. We searched Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 2013, without language restrictions. Meta-analysis was performed using the STATA 12.0 software. Crude odds ratios and 95% confidence intervals were calculated. Eight case-control studies were included, with a total of 2128 asthma patients and 3134 healthy controls.

Relationship between vitamin D (1,25-dihydroxyvitamin D3) receptor gene polymorphisms and primary biliary cirrhosis risk: a meta-analysis

F. Fang, Wang, J., Pan, J., Su, G. H., Xu, L. X., and Li, G., Relationship between vitamin D (1,25-dihydroxyvitamin D3) receptor gene polymorphisms and primary biliary cirrhosis risk: a meta-analysis, vol. 14, pp. 981-988, 2015.

The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary cirrhosis (PBC) risk. We conducted an overall meta-analysis and subgroup meta-analysis based on ethnicity that included a total of 6 eligible studies (672 cases and 1148 controls).

Interleukin-10 polymorphisms associated with susceptibility to acute myeloid leukemia

C. Fei, Yao, X. M., Sun, Y., Gu, X. Z., Yu, L. Q., and Lai, X., Interleukin-10 polymorphisms associated with susceptibility to acute myeloid leukemia, vol. 14, pp. 925-930, 2015.

We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) and the risk of acute myeloid leukemia (AML) in a Chinese population. A total of 167 primary AML cases and 328 healthy control subjects were recruited at the First People’s Hospital of Yunnan Province between March 2009 and January 2012. The polymorphisms rs1800896, rs1800871, and rs1800872 were genotyped by polymerase chain reaction-restriction fragment length polymorphism.

Association between macrophage migration inhibitory factor rs1007888 and GDM

Y. Zhan, Li, C., Chen, J., Yu, S., Gao, Q., Wang, Y. P., and Liu, S. G., Association between macrophage migration inhibitory factor rs1007888 and GDM, vol. 14, pp. 797-804, 2015.

We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study.

Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis

D. W. Suo, Hu, Q., Chen, J., Sun, Q. H., and Guo, H., Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis, vol. 14, pp. 1566-1579, 2015.

Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the TNF-β C804A polymorphism to MI risk.

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