mRNA

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

H. Zhang, Li, J., Zhang, Y., Sun, M., Zhao, P., Zhang, G., Jin, C., Sun, L., He, M., Wang, B., and Zhang, X., ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy, vol. 13, pp. 10215-10222, 2014.

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and clinical outcome. Patients with unresectable, locally advanced or metastatic NSCLC were enrolled between September 2007 and September 2009, and they were followed up until September 2012.

Differential expression analysis of porcine MDH1, MDH2 and ME1 genes in adipose tissues

S. L. Zhou, Li, M. Z., Li, Q. H., Guan, J. Q., and Li, X. W., Differential expression analysis of porcine MDH1, MDH2 and ME1 genes in adipose tissues, vol. 11. pp. 1254-1259, 2012.

Malate dehydrogenases 1 and 2 (MDH1 and MDH2), and malic enzyme 1 (ME1) play important roles in the Krebs cycle for energy metabolism. The mRNA abundance changes of MDH1, MDH2 and ME1 genes were measured across six different adipose tissues from the leaner Landrace and fatty Rongchang pig breeds using quantitative real-time PCR. The mRNA of MDH1, MDH2 and ME1 was more abundant in fatty Rongchang pigs than in leaner Landrace pigs.

Expression profile analysis reveals putative prostate cancer-related microRNAs

H. Song, Liu, Y., Pan, J., and Zhao, S. T., Expression profile analysis reveals putative prostate cancer-related microRNAs, vol. 12, pp. 4934-4943, 2013.

Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abnormally expressed mRNAs and miRNAs, and explored mRNA-target miRNA interrelated pairs to explain the biological functions of miRNA during the progression of PC, thus revealing the occurrence of miRNA-mediated PC.

Up-regulation of Id1 in peripheral blood of psoriatic patients

C. Ronpirin, Achariyakul, M., Tencomnao, T., Wongpiyabovorn, J., and Chaicumpa, W., Up-regulation of Id1 in peripheral blood of psoriatic patients, vol. 9, pp. 2239-2247, 2010.

Although the precise causes of psoriasis are unclear, it is widely accepted that psoriasis is a disorder in which factors in the immune system, enzymes, and other biochemical substances that regulate skin cell division are impaired, leading to rapid proliferation of keratinocytes and incomplete keratinization. Expression of the helix-loop-helix transcription factor Id1 (inhibitor of differentiation/DNA binding), functioning as an inhibitor of differentiation, is known to increase in psoriatic skin.

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