Meta-analysis

Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1βgene and prostate cancer: a systematic review and meta-analysis

Y. Z. Xiang, Jiang, S. B., Zhao, J., Xiong, H., Cui, Z. L., Li, G. B., and Jin, X. B., Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1βgene and prostate cancer: a systematic review and meta-analysis, vol. 13, pp. 6582-6592, 2014.

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the odds ratios (ORs) with corresponding 95% confidence intervals (CIs) of all currently available case-control studies located within PubMed and Embase databases up to December 2012.

Clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) in colorectal cancer: a meta-analysis

Y. Wang and Zeng, T. T., Clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) in colorectal cancer: a meta-analysis, vol. 13, pp. 7102-7112, 2014.

Growing evidence has implicated that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in a spectrum of human cancers. Several observational studies from different parts of the world have been devoted to elucidate the clinical relationship between NGAL and colorectal cancer. This meta-analysis aimed to explore the overall accuracy of NGAL detection for the diagnosis and prognosis of colorectal cancer. Based on comprehensive literature screening on Pubmed, Ovid, and CNKI databases, our screening covered all published papers until March 2013.

Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis

L. L. Zhang, Gong, J., and Liu, C. T., Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis, vol. 13, pp. 7607-7616, 2014.

Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We searched electronic databases including SCI, EMBASE, Ovid, and PubMed. Reviewers working independently and in duplicate extracted study characteristics, quality, and the outcomes.

Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer

X. Tan, Wang, Y. Y., Chen, X. Y., Xian, L., Guo, J. J., Liang, G. B., and Chen, M. W., Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer, vol. 13, pp. 7437-7446, 2014.

The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-analysis. A comprehensive literature search was performed using the Pubmed and Embase databases. Odds ratios with 95% confidence intervals were used to assess the strength of associations.

MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis

J. Z. Guan, Wu, M., Xiao, Y. Z., Zhou, J. S., and Wang, Z. D., MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis, vol. 13, pp. 7356-7364, 2014.

Numerous studies have evaluated the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis of the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. Only seven case-control studies were retrieved, with a total of 4258 patients and 3454 healthy controls.

Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis

C. Ma, Zhou, Q. L., Deng, Y. J., Liang, X., Wu, D. P., and Dong, Y. Z., Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis, vol. 13, pp. 7791-7799, 2014.

The vitamin D receptor BsmI gene polymorphism is reportedly associated with low bone mineral density (BMD) in postmenopausal women, but results from previous studies are conflicting. In the present study, we investigated the association between this polymorphism and the risk of low BMD through a meta-analysis of published studies. A literature search of the Pubmed, Embase, and CNKI databases from inception through July 2013 was conducted. The meta-analysis was performed using the STATA 12.0 software.

Association between the EGF rs4444903 polymorphism and liver cancer susceptibility: a meta-analysis and meta-regression

Y. L. Li, Tian, Z., Zhao, L., and Zhang, C. L., Association between the EGF rs4444903 polymorphism and liver cancer susceptibility: a meta-analysis and meta-regression, vol. 13, pp. 8066-8079, 2014.

Emerging evidence suggests that a common functional polymorphism, rs4444903 (A>G), in the EGF gene might impact an individual’s susceptibility to liver cancer; however, individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between the EGF rs4444903 polymorphism and liver cancer risk. A literature search was conducted in the PubMed, Embase, Web of Science, and CBM databases from inception through May 1st, 2013.

Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom: a meta-analysis

H. C. Qu, Yan, S., Zhang, X. L., Zhu, X. W., Liu, Y. L., and Wang, P., Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom: a meta-analysis, vol. 13, pp. 8609-8619, 2014.

To examine whether urinary tract nerve growth factor (uNGF) could be a biomarker for overactive bladder (OAB) symptom, we conducted a comprehensive meta-analysis of 8 case-control studies. In all the studies considered, patients with OAB symptom had a higher uNGF level compared to healthy people. In addition, patients had a significantly lower uNGF level after successful treatment. In the subgroup analysis, we found that patients with OAB-wet symptom had a higher uNGF level than patients with OAB-dry symptom.

An elevated plasma level of visfatin increases the risk of myocardial infarction

Y. Yang, Li, Z., Tao, H. F., Qi, X. Y., Wang, W. L., Yang, L., Wang, H., and Xu, P., An elevated plasma level of visfatin increases the risk of myocardial infarction, vol. 13, pp. 8586-8595, 2014.

Visfatin, an adipocytokine involved in metabolic and immune disorders, plays an important role in the etiology of cardiovascular disease. Recent evidence has shown that an elevated plasma level of visfatin may increase the risk of myocardial infarction (MI), but individual published studies have shown inconclusive results. This study aimed to obtain a more precise estimate of the association between the plasma visfatin level and MI risk through a detailed meta-analysis of studies published in peer-reviewed journals.

KCNE1 112G>A polymorphism and atrial fibrillation risk: a meta-analysis

H. G. Han, Wang, H. S., Yin, Z., Jiang, H., Fang, M., and Han, J., KCNE1 112G>A polymorphism and atrial fibrillation risk: a meta-analysis, vol. 13, pp. 8367-8377, 2014.

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this meta-analysis, we derived a more precise estimation of the association between the KCNE1 112G>A polymorphism and AF risk.

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