Meta-analysis

DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis

C. H. Liu, Tao, T., Jiang, L., Xu, B., Zhang, L., Lu, K., Zhang, X. W., Chen, S. Q., Liu, D. C., and Chen, M., DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis, vol. 14, pp. 3640-3649, 2015.

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To clarify the role of DNMT3A polymorphisms in cancer, we conducted a meta-analysis of 2014 cases and 3089 control subjects.

T174M polymorphism in the angiotensinogen gene and risk of myocardial infarction: a meta-analysis

P. Y. Hu, Wang, Y. W., Pang, X. H., and Wang, H. W., T174M polymorphism in the angiotensinogen gene and risk of myocardial infarction: a meta-analysis, vol. 14, pp. 3767-3774, 2015.

Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensive search was conducted to identify all published articles regarding the association between the AGT gene T174M polymorphism and MI risk from different databases.

Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis

J. H. Qi, Shi, N., Chen, Y. J., and Nie, G., Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis, vol. 14, pp. 3869-3876, 2015.

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T polymorphism and psoriasis risk were retrieved from the PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases.

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk

R. Zhu, Bi, L. Q., Kong, H., Tilley, S. L., Wang, H., and Xie, W. P., Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk, vol. 14, pp. 3590-3600, 2015.

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval.

Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma

J. H. Zhong, Li, L. Q., Mo, X. S., Gong, W. F., Ma, L., Chen, J., and You, X. - M., Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma, vol. 14, pp. 4133-4141, 2015.

Carcinogenesis of breast carcinoma is very complicated. Previous studies have suggested conflicting results regarding the association between Tyr113His and His139Arg microsomal epoxide hydrolase (mEH) gene polymorphisms and risk of breast carcinoma. We conducted a meta-analysis to examine the relationship between these polymorphisms and breast carcinoma risk. We searched the PubMed, EMBASE, and Google Scholar databases to identify relevant studies.

Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis

G. Q. Zhou, Meng, H., Wang, J. R., Sun, F. X., Wang, X. J., Wang, R. B., and Wang, X. B., Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis, vol. 14, pp. 4767-4777, 2015.

Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk. A digital search was performed of the MEDLINE EMBASE, CNKI, and CBM databases to identify relevant articles published up to February 18, 2014.

Meta-analysis of differentially expressed genes in ankylosing spondylitis

Y. H. Lee and Song, G. G., Meta-analysis of differentially expressed genes in ankylosing spondylitis, vol. 14, pp. 5161-5170, 2015.

The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in ankylosing spondylitis (AS). We performed a meta-analysis using the integrative meta-analysis of expression data program on publicly available microarray AS Gene Expression Omnibus (GEO) datasets. We performed Gene Ontology (GO) enrichment analyses and pathway analysis using the Kyoto Encyclopedia of Genes and Genomes. Four GEO datasets, including 31 patients with AS and 39 controls, were available for the meta-analysis.

Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis

K. Cui, Ge, X. Y., and Ma, H. L., Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis, vol. 14, pp. 5210-5220, 2015.

The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify articles that have reported an association between the TNF-α +489 G/A polymorphism and COPD risk.

TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis

Y. H. Lee and Song, G. G., TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis, vol. 14, pp. 4966-4977, 2015.

The purpose of this study was to examine whether tu­mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex­amining the association between TNF-α -308 A/G and -238 A/G poly­morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-α -308 A al­lele and glaucoma [odds ratio (OR) = 1.403, 95% confidence inter­val (CI) = 0.784-2.513, P = 0.254].

Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis

T. T. Zhao, Shen, L. L., Zhang, X. L., Gu, D. Y., Zhang, Q., Huo, X. Y., Tang, C. J., and Chen, J. F., Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis, vol. 14, pp. 5602-5614, 2015.

Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A comprehensive search was conducted to identify all eligible studies of the SHMT1 rs1979277 polymorphism and solid tumor risk.

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