GSTP1

Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis

M. Kuang, Xu, W., Cao, C. X., Shen, L. L., Chang, J., Zhang, X. L., Chen, J. F., Tang, C. J., Kuang, M., Xu, W., Cao, C. X., Shen, L. L., Chang, J., Zhang, X. L., Chen, J. F., and Tang, C. J., “Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis”, vol. 15, p. -, 2016.

Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a comprehensive estimation of this association. A total of 20,615 cases and 20,481 controls from thirty-six case-control trials were extracted from an online literature survey.

Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer

J. Y. Liu, Li, L. R., and Liu, Q. M., “Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer”, vol. 14, pp. 10331-10337, 2015.

We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymorphism analysis.

Polymorphisms and allele frequencies of glutathione S-transferases A1 and P1 genes in the Polish population

M. Skrzypczak-Zielinska, Zakerska-Banaszak, O., Tamowicz, B., Sobieraj, I., Drweska-Matelska, N., Szalata, M., Slomski, R., and Mikstacki, A., “Polymorphisms and allele frequencies of glutathione S-transferases A1 and P1 genes in the Polish population”, vol. 14, pp. 2850-2859, 2015.

Glutathione S-transferases (GST) A1 and P1 are crucial enzymes involved in the biotransformation of drugs, carcinogens, and toxins, and their activity may influence drug response, susceptibility to diseases, and carcinogenesis. The genes encoding these enzymes, GSTA1 and GSTP1, have been examined in many studies because of their genetic variability, which may affect enzymatic activity. The goal of this study was to determine the distribution of the alleles GSTA1*A/*B and GSTP1*A, *B, and *C in the Polish population.

Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis

Q. F. Li, Li, Q. Y., Gao, A. R., and Shi, Q. F., “Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis”, vol. 14, pp. 6762-6772, 2015.

Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). We therefore conducted a meta-analysis to obtain a more precise estimate of this association. By searching the Cochrane Library, CBM, EMBASE, PubMed, and the Web of Science, we tabulated and analyzed parameters from each study. Results were summarized by meta-analyses using the version 12.0 STATA software. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were also calculated in this analysis.

Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients

A. Maver, Medica, I., Salobir, B., Tercelj, M., and Peterlin, B., “Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients”, vol. 9, pp. 58-68, 2010.

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, proteomic and linkage studies of sarcoidosis.

GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas

A. C. Custódio, Almeida, L. O., Pinto, G. R., Santos, M. J., Almeida, J. R. W., Clara, C. A., Rey, J. A., and Casartelli, C., “GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas”, vol. 9, pp. 2328-2334, 2010.

Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of developing some types of tumors. We examined GSTP1 Ile105Val polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples.

Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population

Q. Qadri, Sameer, A. S., Shah, Z. A., Hamid, A., Alam, S., Manzoor, S., and Siddiqi, M. A., “Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population”, vol. 10, pp. 3038-3045, 2011.

Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1.

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