GSTM1

Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis

B. Zhu, Yin, L., and Zhang, J. Y., “Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis”, vol. 14, pp. 18851-18858, 2015.

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 control subjects. A systematic literature search (for articles published up to September 2014) utilizing Google Scholar and PubMed was conducted.

Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis

H. Liu, Ma, H. F., and Chen, Y. K., “Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis”, vol. 14, pp. 1385-1392, 2015.

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a random-effect model to pool the odds ratios (ORs) and 95% confidence intervals (CIs).

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil

deP. R. A. Júnior, Reis, G. Mdos, Silva, K. S. Fe, Rodrigues, D. A., Gomes, M. C. S., Martins, J. V. M., da Costa, I. R., Freitas, G. A., and Moura, K. K. V. O., “Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil”, vol. 14, pp. 6173-6181, 2015.

The first reports about pterygium date back to Hip­pocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascular­ized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea.

Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population

A. Sandoval-Carrillo, Aguilar-Duran, M., Vázquez-Alaniz, F., Castellanos-Juárez, F. X., Barraza-Salas, M., Sierra-Campos, E., Téllez-Valencia, A., La Llave-León, O., and Salas-Pacheco, J. M., “Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population”, vol. 13, pp. 2160-2165, 2014.

Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutathione S-transferases (GST) M1 and T1 genes and the risk of preeclampsia. This case-control study involved 112 preeclamptic and 233 normoevolutive pregnant women. The null polymorphisms were genotyped by multiplex polymerase chain reaction (PCR).

Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goiânia Central-West Region of Brazil

C. T. X. Silva, Costa, N. B., Silva, K. S. F., Silva, R. E., and Moura, K. K. V. O., “Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goiânia Central-West Region of Brazil”, vol. 13, pp. 8870-8875, 2014.

In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based methods. Polymorphism frequencies were compared using the X2 test and odds ratio (α = 0.05).

GSTM1 polymorphism in patients with primary open-angle glaucoma

A. M. Barbosa, Frare, A. B., Costa, N. B., Silva, R. E., and Moura, K. K. V. O., “GSTM1 polymorphism in patients with primary open-angle glaucoma”, vol. 11, pp. 3256-3262, 2012.

Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) are a group of drug-metabolizing enzymes of phase-II that act in the detoxification of xenobiotics and inactivate end-products formed as secondary metabolites during oxidative stress.

GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goiás, Brazil

A. B. Frare, Barbosa, A. M., Costa, I. R., Souza, S. R., Silva, R. C. P. C., Bordin, B. M., Júnior, C. L. Ribeiro, and Moura, K. K. V. O., “GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goiás, Brazil”, vol. 12, pp. 2764-2770, 2013.

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of present/absent polymorphisms of GSTM1 and GSTT1 in 50 women diagnosed with endometriosis and in a control group of 46 women without complaints related to this pathology.

Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and glutathione-S-transferase enzyme T1 and M1 with retinopathy of prematures

M. Yildiz, Karkucak, M., Yakut, T., Gorukmez, O., and Ozmen, A., “Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and glutathione-S-transferase enzyme T1 and M1 with retinopathy of prematures”, vol. 9, pp. 2131-2139, 2010.

One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of the ACE gene.

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

A. C. F. Finotti, Silva, R. C. P. Costa e, Bordin, B. M., Silva, C. T. X., and Moura, K. K. V. O., “Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility”, vol. 8, pp. 1093-1098, 2009.

Male infertility is a heterogeneous disorder, with vari­ous genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxi­fying enzymes of phase II drug metabolism can modify their expres­sion or function, affecting the biotransformation of toxic compounds to which the male reproductive system is exposed.

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