Genetic polymorphism

Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration

Z. H. Tian, Shi, F., Zhong, F. G., Bai, D. P., and Zhang, X. Y., “Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration”, vol. 14, pp. 2461-2470, 2015.

The neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body and passive protection to the offspring. Changes in FcRn expression levels caused by genetic polymorphisms of Fcgrt, which encodes FcRn, may lead to inter-individual differences in colostrum IgG levels in sheep.

Association between polymorphism of β3-adrenoceptor gene and overactive bladder: a meta-analysis

H. C. Qu, Zhang, W., Liu, Y. L., and Wang, P., “Association between polymorphism of β3-adrenoceptor gene and overactive bladder: a meta-analysis”, vol. 14, pp. 2495-2501, 2015.

Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we conducted a meta-analysis to explore the association between the Trp64Arg polymorphism and OAB risk. We examined 2 case-control studies, including a total of 149 OAB cases and 270 healthy controls.

Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population

H. Xia, Luo, Q., Li, X. X., and Yang, X. L., “Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population”, vol. 14, pp. 2978-2985, 2015.

Recent genome-wide association studies identified 11 risk loci in different populations of familial and sporadic Parkinson’s disease (PD) patients. Few loci have been verified in different European and Asian populations. We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with susceptibility to PD in the Xinjiang Uygur and Han populations. This case-control study included 312 PD patients (130 Uygur and 182 Han) and 359 control subjects (179 Uygur and 180 Han).

Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population

R. P. Lin, Yao, C. Y., and Ren, D. X., “Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population”, vol. 14, pp. 3142-3148, 2015.

Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 cancer-free controls for the present study and analyzed the distribution of the PTGS2 genotypes and haplotypes.

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

G. L. Shi, Yang, L., Sun, Y., Yin, Y. J., and Song, C. X., “MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis”, vol. 14, pp. 4035-4040, 2015.

Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and Korean populations.

Genetic polymorphism at the KIR gene locus: determination of gene, genotype, and haplotype frequencies in the Xinjiang Han population

G. - Y. Lin, Yu, B., Hu, W. - J., Zhang, Y. - Z., Zuo, X. - J., and Wang, Y. - B., “Genetic polymorphism at the KIR gene locus: determination of gene, genotype, and haplotype frequencies in the Xinjiang Han population”, vol. 14, pp. 6213-6222, 2015.

The aim of this study was to explore the genetic polymorphism, genotype, and haplotype characteristics of the KIR locus in the Xinjiang Han population in order to establish a foundation for future analysis of the relationship between KIR genes and disease. KIR genes were detected by sequence-specific primer-polymerase chain reaction in 184 randomly selected, healthy individuals from the Han population in Xinjiang, China. Standard genotype and haplotype analyses were conducted using Hsu’s standards classified for analysis.

Development of novel polymorphic microsatellite markers for the silver fox (Vulpes vulpes)

S. Q. Yan, Bai, C. Y., Qi, S. M., Li, Y. M., Li, W. J., and Sun, J. H., “Development of novel polymorphic microsatellite markers for the silver fox (Vulpes vulpes)”, vol. 14, pp. 5890-5895, 2015.

The silver fox (Vulpes vulpes), a coat color variant of the red fox, is one of the most important fur-bearing animals. To date, development of microsatellite loci for the silver fox has been limited and mainly based on cross-amplification by using canine SSR primers. In this study, 28 polymorphic microsatellite markers were isolated and identified for silver fox through the construction and screening of an (AC)n-enriched library. The number of alleles per locus ranged from 2 to 8 based on 48 individuals tested.

Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility

S. E. Aydos, Karadağ, A., Özkan, T., Altınok, B., Bunsuz, M., Heidargholizadeh, S., Aydos, K., and Sunguroĝlu, A., “Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility”, vol. 14, pp. 6330-6339, 2015.

Infertility affects 1 in 6 couples and approximately 1 in 25 men. Male factor infertility is a major cause of spermatogenic anomalies, the causes of which are largely unknown. Impaired repro­ductive functions in men might result from physiological, genetic, and/or environmental factors such as xenobiotics. The multi-drug re­sistance1 (MDR1) gene encodes a P-glycoprotein which has a role in the active transport of various substrates providing protection of somatic cells from potentially toxic substances, including xenobi­otics.

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis

X. L. Zhang, Zhang, X. J., Chen, Y., Zhang, Y. M., Zhang, Q., Cao, C. X., Gu, D. Y., Shi, J. F., Gong, Y. L., Chen, J. F., and Tang, C. J., “Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis”, vol. 13, pp. 1373-1382, 2014.

A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was significantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this polymorphism and lung cancer risk more precisely, we performed a meta-analysis of eight eligible studies involving 9935 cases and 11,261 controls.

Genetic variability and phylogenetic aspects in species of the genus Macrobrachium

A. L. Guerra, Lima, A. V. B., Júnior, R. V. Lucato, Chiachio, M. C., Taddei, F. G., and Castiglioni, L., “Genetic variability and phylogenetic aspects in species of the genus Macrobrachium”, vol. 13, pp. 3646-3655, 2014.

The genus Macrobrachium includes prawns, which are widely distributed in lakes, floodplains, and rivers in tropical and subtropical regions of South America. This genus presents nearly 210 known species with great ecological and economic importance. However, few studies are related to the biology of these crustaceans. In this study, we analyzed the genetic variability and phylogenetic relationship between Macrobrachium amazonicum and Macrobrachium jelskii, which are closely related species.

Pages

Subscribe to Genetic polymorphism