Genetic

GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer

A. L. Oliveira, Rodrigues, F. F. O., Santos, R. E., Aoki, T., Rocha, M. N., Longui, C. A., and Melo, M. B., GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer, vol. 9, pp. 1045-1053, 2010.

The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant chemotherapy in the treatment of stage II and III breast cancer.

Estimation of genetic parameters and variance components for growth traits in Romosinuano cattle in the Colombian humid tropics

R. M. Sarmiento and Garcia, J. P., Estimation of genetic parameters and variance components for growth traits in Romosinuano cattle in the Colombian humid tropics, vol. 6, pp. 482-491, 2007.

(Co)variance components and genetic parameters were estimated for body weights of a Romosinuano herd located in Sinú Valley, Cordoba, Colombia. Restricted maximum likelihood methods were used with a univariate animal model for birth weight, weaning weight (270 days), 16-month weight (480 days), weaning daily gain, and post-weaning daily gain. Models included random animal direct and maternal genetic effects, maternal permanent environmental effect (c2), and sex-year-month of birth and age of dam, as fixed effects.

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