Epidemiology

Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking

T. M. Silva, Marques, C. R., Filho, M. F. Marques, Marques, A. B., Di Pietro, G., and Rios-Santos, F., Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking, vol. 13, pp. 528-537, 2014.

Polymorphisms in genes encoding xenobiotic-metabolizing enzymes might explain differences in the susceptibility to upper aerodigestive tract (UADT) cancers in individuals exposed to tobacco or other carcinogens. The present study aimed to evaluate the association of polymorphisms in the glutathione S-transferase (GST) candidate genes GSTM1, GSTT1, and GSTP1 with the risk of UADT cancers. GST gene polymorphisms were determined in 116 individuals with UADT cancer and 224 healthy controls using polymerase chain reaction-based methods.

Human papillomavirus infection in Brazilian women with normal cervical cytology

P. M. Miranda, Pitol, B. C. V., Moran, M. S., Silva, N. N. T., Felix, P. M., Lima-Filho, J. L., Carneiro, C. M., Silva, I. D. C. G., Carvalho, R. F., Lima, A. A., Beçak, W., and Stocco, R. C., Human papillomavirus infection in Brazilian women with normal cervical cytology, vol. 11, pp. 1752-1761, 2012.

We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples of 399 women, received for routine evaluation in the Health Department of Ouro Preto, MG, Brazil, were subjected to HPV-DNA testing by PCR with MY09/11 primers. HPV-positive specimens were typed by RFLP.

Phylogenetic analyses of the hemagglutinin gene of wild-type strains of canine distemper virus in southern Brazil

F. J. Negrão, Gardinali, N. R., Headley, S. A., Alfieri, A. A., Fernandez, M. A., and Alfieri, A. F., Phylogenetic analyses of the hemagglutinin gene of wild-type strains of canine distemper virus in southern Brazil, vol. 12, pp. 2549-2555, 2013.

This study examined the phylogenetic relationship of strains of canine distemper virus (CDV) collected from Paraná State, Brazil, based on the hemagglutinin gene. Urine samples were collected from 4 dogs from northern Paraná State that demonstrated clinical manifestations of canine distemper. The participation of CDV was initially confirmed by RT-PCR targeting the nucleocapsid protein, after which the complete hemagglutinin gene was sequenced from each sample. Sequences were deposited in and compared with those already in GenBank.

Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil

J. Coser, T. Boeira, daRocha, Simon, D., Fonseca, A. S. Kazantzi, Ikuta, N., and Lunge, V. R., Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil, vol. 12, pp. 4276-4285, 2013.

Human papillomavirus (HPV) infection is a common viral sexually transmitted infection and the main cause of cervical cancer in women worldwide. Epidemiological data on the prevalence of HPV in a given population is essential for the establishment of effective prevention strategies. The aim of this study was to determine HPV prevalence in women who attended a public health service within an urban center in Brazil.

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