Candidate genes

Identification of the transcriptionally active cytochrome P450 repertoire in Coffea arabica

S. T. Ivamoto, Domingues, D. S., Vieira, L. G. E., and Pereira, L. F. P., “Identification of the transcriptionally active cytochrome P450 repertoire in Coffea arabica”, vol. 14, pp. 2399-2412, 2015.

Cytochrome P450s (P450s) comprise a gene superfamily encoding enzymes that are involved in diverse plant metabolic pathways that produce primary and secondary metabolites such as phenylpropanoids, terpenoids, nitrogen-containing compounds, and plant hormones. They comprise one of the most diverse gene families in plant evolution.

Transcriptome network analysis of potential candidate genes for heart failure

J. Chen, Wang, H. Y., and Zeng, C. Y., “Transcriptome network analysis of potential candidate genes for heart failure”, vol. 12, pp. 4687-4697, 2013.

The purpose of this study was to examine the hypothesis that a transcriptome network can be developed through a set of transcription factors regulated by the expression of various genes induced by dilated cardiomyopathy can be identified and modulated to respond to heart failure. We searched for significant pathways related to dilated cardiomyopathy using the GSE4172 microarray data to identify potential genes related to heart failure.

Study of candidate genes for dyslexia in Brazilian individuals

M. C. C. M. Svidnicki, Salgado, C. A., Lima, R. F., Ciasca, S. M., Secolin, R., Pomilio, M. C. A., Junqueira, P. A., Pinto, M. S., Pereira, M. M., and Sartorato, E. L., “Study of candidate genes for dyslexia in Brazilian individuals”, vol. 12, pp. 5356-5364, 2013.

Dyslexia or reading disability (RD) is the most common childhood learning disorder and a significantly heritable trait. Many recent studies have investigated the genetic basis of dyslexia, and several candidate genes have been proposed. Among these, DCDC2 and KIAA0319 have emerged as the strongest candidate genes for dyslexia; however studies have not provided uniformly supportive results. The aim of this study was to assess the contribution of proposed candidate genes to the molecular etiology of dyslexia in a Brazilian sample.

Prospecting candidate SNPs for backfat in Canchim beef cattle

G. B. Veneroni, Meirelles, S. L., Grossi, D. A., Gasparin, G., Ibelli, A. M. G., Tizioto, P. C., Oliveira, H. N., Alencar, M. M., and Regitano, L. C. A., “Prospecting candidate SNPs for backfat in Canchim beef cattle”, vol. 9, pp. 1997-2003, 2010.

Canchim is a composite cattle breed developed in Brazil for beef production. One of the breeding objectives is to increase fat deposition. QTLs for fat thickness and/or marbling have been reported on BTA4 and BTA14. The IGFBP3 and DDEF1 genes, mapped to BTA4 and BTA14, respectively, affect adipogenesis. We looked for SNPs in the IGFBP3 and DDEF1 genes that could be associated with backfat thickness in Canchim beef cattle.

Genetic polymorphism of the kappa-casein gene in Brazilian cattle

A. L. S. Azevedo, Nascimento, C. S., Steinberg, R. S., Carvalho, M. R. S., Peixoto, M. G. C. D., Teodoro, R. L., Verneque, R. S., Guimarães, S. E. F., and Machado, M. A., “Genetic polymorphism of the kappa-casein gene in Brazilian cattle”, vol. 7, pp. 623-630, 2008.

Frequencies of κ-casein gene alleles were determined in 1316 animals from the Brazilian Bos indicus genetic groups (Sindhi cows, Gyr sires, Gyr cows, Guzerat sires, Guzerat cows, Nellore sires, and Gyr x Holstein crossbreds) by means of polymerase chain reaction-restriction fragment length polymorphism analysis using two independent restriction nucleases (Hinf I and HaeIII). The genotyping of κ-casein alleles (A and B) is of practical importance, since the B allele is found to correlate with commercially valuable parameters of cheese yielding efficiency.

Association of BoLA-DRB3.2 alleles with tick (Boophilus microplus) resistance in cattle

M. L. Martinez, Machado, M. A., Nascimento, C. S., Silva, M. V. G. B., Teodoro, R. L., Furlong, J., Prata, M. C. A., Campos, A. L., Guimarães, M. F. M., Azevedo, A. L. S., Pires, M. F. A., and Verneque, R. S., “Association of BoLA-DRB3.2 alleles with tick (Boophilus microplus) resistance in cattle”, vol. 5, pp. 513-524, 2006.

Losses caused by bovine tick burdens in tropical countries have a tremendous economic impact on production systems. Besides reducing production, this parasite can cause death in the most susceptible animals. The use of commercial acaricides has been the major method of control, but their misuse has led to tick resistance to many chemicals. More recently, vaccines have been used in some countries without solving the problem completely.

DGAT1 K232A polymorphism in Brazilian cattle breeds

G. A. Lacorte, Machado, M. A., Martinez, M. L., Campos, A. L., Maciel, R. P., Verneque, R. S., Teodoro, R. L., Peixoto, M. G. C. D., Carvalho, M. R. S., and Fonseca, C. G., “DGAT1 K232A polymorphism in Brazilian cattle breeds”, vol. 5, pp. 475-482, 2006.

Recent reports identified DGAT1 (EC 2.3.1.20) harboring a lysine to alanine substitution (K232A) as a candidate gene with a strong effect on milk production traits. Our objective was to estimate the frequency of the DGAT1 K232A polymorphism in the main Zebu and Taurine breeds in Brazil as well as in Zebu x Taurine crossbreds as a potential QTL for marker-assisted selection.

Subscribe to Candidate genes