Antimutagenicity

Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)

P. L. de Freitas, Dias, A. C. S., Moreira, V. R., Monteiro, S. G., and Pereira, S. R. F., Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae), vol. 14, pp. 9745-9752, 2015.

The mutagenic and antimutagenic activities of triterpene betulinic acid {3b-3-hydroxy-lup-20(29)-en-28-oic} isolated from the roots of Scoparia dulcis (Scrophulariaceae) were analyzed using the somatic mutation and recombination test (SMART) in the wings of Drosophila melanogaster. The mutagenic potential of betulinic acid was evaluated at 3 different concentrations (1.64, 3.28, and 6.57 mM).

Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis

S. D. Navarro, Mauro, M. O., Pesarini, J. R., Ogo, F. M., and Oliveira, R. J., Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis, vol. 14, pp. 1679-1691, 2015.

Resistant starch is formed from starch and its degradation products and is not digested or absorbed in the intestine; thus, it is characterized as a fiber. Because fiber intake is associated with the prevention of DNA damage and cancer, the potential antigenotoxic, antimutagenic, and anticarcinogenic capabilities of resistant starch from green banana flour were evaluated.

Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa

I. Felicidade, Lima, J. D., Pesarini, J. R., Monreal, A. C. D., Mantovani, M. S., Ribeiro, L. R., and Oliveira, R. J., Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa, vol. 13, pp. 9986-9996, 2014.

Polyphenolic compounds present in rosemary were found to have antioxidant properties, anticarcinogenic activity, and to increase the detoxification of pro-carcinogens. The aim of the study was to determine the effect the aqueous extract of rosemary (AER) on mutagenicity induced by methylmethane sulfonate in meristematic cells of Allium cepa, as well as to describe its mode of action. Anti-mutagenicity experiments were carried out with 3 different concentrations of AER, which alone showed no mutagenic effects.

Mineral content is related to antioxidant and antimutagenic properties of grape juice

C. Dani, Oliboni, L. S., Prá, D., Bonatto, D., Santos, C. E. I., Yoneama, M. L., Dias, J. F., Salvador, M., and Henriques, J. A. P., Mineral content is related to antioxidant and antimutagenic properties of grape juice, vol. 11, pp. 3154-3163, 2012.

Grape juices are an important source of food antioxidants. Unfortunately, there is little data about the mineral composition and the antioxidant, mutagenic and antimutagenic activities of grape juice in eukaryote cells. We evaluated the mineral contents (Mg, Ca, Mn, Fe, Cu, Zn, Si, S, Cl) of grape juices, the antioxidant, mutagenic and/or antimutagenic activities of the juices in the yeast Saccharomyces cerevisiae, and looked for a possible association between mineral content and antioxidant, mutagenic and/or antimutagenic activities of juice samples.

Evaluation of the mutagenicity and antimutagenicity of soy phytoestrogens using micronucleus and comet assays of the peripheral blood of mice

A. M. Niwa, Oliveira, R. J., and Mantovani, M. S., Evaluation of the mutagenicity and antimutagenicity of soy phytoestrogens using micronucleus and comet assays of the peripheral blood of mice, vol. 12, pp. 519-527, 2013.

Studies show that soy imparts many favorable properties in the human body, including the prevention of chronic diseases such as osteoporosis, heart disease, cancer, and diabetes. Soy is rich in isoflavones, and it is a candidate for the chemoprevention of diseases owing to its low toxicity. In this study, a soy phytoestrogen (with high levels of the isoflavones genistin and daidzein) was tested in mice to investigate its mutagenicity and genotoxicity using micronucleus and comet assays of mouse peripheral blood.

Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells

L. S. Coelho, Felício, L. P., Miranda, C. T., Vale, C. R., Lima, D. C. S., Duarte, S. R., Ferreira, H. D., L. Chen, C., Carvalho, S., and da Silva, E. M., Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells, vol. 10, pp. 75-85, 2011.

Mutagenic and antimutagenic activities of the medicinal plant Duguetia furfuracea were assessed using SMART/wing and ring-X-loss tests. For the ring-X-loss test, 2- to 3-day-old Drosophila melanogaster ring-X-lineage males and virgin ywsn3 females received D. furfuracea infusion at doses of 0.085, 0.042, or 0.014 g/mL for 24 h. We found that D. furfuracea did not produce any mutagenic effects in D. melanogaster germinative cells. The somatic cells of D.

Cytotoxic, mutagenic and antimutagenic screening of Arenosclera brasiliensis acetone and ethanol extracts

L. Stankevicins, Aiub, C. A. F., Mazzei, J. L., Lôbo-Hajdu, G., Lôbo-Hajdu, G., and Felzenszwalb, I., Cytotoxic, mutagenic and antimutagenic screening of Arenosclera brasiliensis acetone and ethanol extracts, vol. 7, pp. 542-548, 2008.

The marine environment is a rich source of biologically active compounds with pharmacological properties. Marine organisms often produce secondary metabolites with structural features different from those produced by terrestrial ones, and the Phylum Porifera seems to be one of the most productive in this sense. This study was undertaken to provide data on mutagenic and antimutagenic activities from an acetone (Areac) and an ethanol (Areet) extract obtained from Arenosclera brasiliensis, an endemic Brazilian sponge.

Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow

J. B. Vilar, Leite, K. R., and L. Chen, C., Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow, vol. 8, pp. 328-333, 2009.

Ginkgo biloba (Egb 761) extract, the most prescribed phytomedicine in Europe for the treatment of cerebral insufficiency and vascular diseases, was tested for its possible protective effects against mitomycin C (MMC)- and cyclophosphamide (CP)-induced mutagenicity using the micronucleus test in mouse bone marrow. The extract was co-administered to mice at doses of 50, 100 and 200 mg/kg (po) with 4 mg/kg (ip) MMC or 24 mg/kg (ip) CP.

Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress

A. C. T. S. Júnior, Asad, L. M. B. O., de Oliveira, E. B., Kovary, K., Asad, N. R., and Felzenszwalb, I., Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress, vol. 4, pp. 94-99, 2005.

Carotenoids are 40-carbon molecules with conjugated double bonds, making them particularly effective for quenching free radicals. They have always been believed to possess anticancer properties, which could be due to their antioxidant potential. Norbixin is an unusual dicarboxylic water-soluble carotenoid present as a component in the pericarp of the seeds of Bixa orellana L. (from the Bixaceae family), a tropical shrub commonly found in Brazil.

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