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Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant

O. F. Khabour, Alzoubi, K. H., Al-Azzam, S. I., and Mhaidat, N. M., Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant, vol. 12, pp. 801-808, 2013.

The multidrug resistance gene (MDR1 or ABCB1) codes for P-glycoprotein, which plays an important role in regulating absorption, distribution, and elimination of drugs. We examined MDR1 gene variants in 100 unrelated subjects from various regions of Jordan. The MDR1 gene was scanned using direct sequencing. Six rare variants in MDR1 were detected, including a new variant, T3075A. This variant did not affect the protein sequence (synonym for threonine).

Association of the estrogen receptor-β gene RsaI and AluI polymorphisms with human idiopathic thin endometrium

A. W. Le, Wang, Z. H., Yuan, R., Shan, L. L., Xiao, T. H., Zhuo, R., and Shen, Y., Association of the estrogen receptor-β gene RsaI and AluI polymorphisms with human idiopathic thin endometrium, vol. 12, pp. 5978-5985, 2013.

The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (controls) were included in the study. RsaI and AluI polymorphisms of the ER-β gene were analyzed with polymerase chain reaction-restriction fragment length polymorphism.

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