HAEMATOLOGICAL PARAMETERS AND ITS CORRELATION WITH SEVERITY OF DIABETIC KETOACIDOSIS
DOI:
https://doi.org/10.4238/y2jwb375Keywords:
Diabetic ketoacidosis; Pediatrics; Hematological parameters; Total leukocyte count; Neutrophil-to-lymphocyte ratio; Cerebral edemaAbstract
Background: Diabetic ketoacidosis (DKA) is the most common acute hyperglycemic emergency in children with type 1 diabetes mellitus and is associated with significant morbidity and mortality. DKA induces a systemic inflammatory response, often altering hematological parameters and mimicking infection.
Objectives: To evaluate the correlation between hematological parameters and DKA severity in pediatric patients, and assess the association between neutrophil-to-lymphocyte ratio (NLR) and cerebral edema.
Methods: This retrospective single-center study included children aged 1–18 years admitted with DKA between January 2024 and March 2025. Hematological parameters including TLC, ANC, NLR, PLR, PMR, eosinophil count, monocyte count, and HbA1c were analyzed according to ISPAD 2022 criteria.
Results: Fifty-four children were included. TLC showed a significant positive correlation with DKA severity (p=0.036).
Conclusion: TLC may serve as a simple accessible marker correlating with DKA severity in pediatric patients.
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