GC - MS PROFILING OF MAHAMASHA TAILA AND ITS ROLE IN SENSORINEURAL HEARING LOSS

Abstract

Mahamasha taila is an Ayurvedic oil preparation described in Bhaishajyaratnavali under Vatavyadhi Chikitsa prakarana.It is a preparation which gives excellent results in neurological cases. Traditionally it is also used as Nasya and Karnapurana for neurological and auditory disorders. The present study aimed to analyse the phytoconstituents of Mahamashataila using Gas Chromatography – Mass Spectometry (GC-MS) and to corelate its bioactive components with possible otoprotective and neuro regenerative effects which is helpful in managing Sensorineural hearing loss). The GC–MS analysis revealed 50 phytoconstituents, with major peaks corresponding to 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester (55.66%), Heptadecanoic acid, 14-methyl-, methyl ester (6.12%), and Octadecanoic acid, 3-hydroxy-2-tetradecyl-, methyl ester (14.76%). These compounds are having anti-inflammatory, antioxidant and neuroprotective properties. These results provide a scientific basis for the therapeutic use of Mahamasha taila in the management of SNHL.