EFFECT OF BILWADI AGADA ON BODY WEIGHT IN PARACETAMOL-INDUCED HEPATOTOXICITY: AN ANIMAL STUDY

Abstract

Paracetamol (Also Known as Acetaminophen, N-acetyl-p-aminophenol) is a commonly used over-the-counter medication with potent analgesic and antipyretic properties. It is effective in mild to moderate pain such as headache, dysmenorrhoea, post-operative pain, and toothache. It is very safe when used in limited doses, but at the same time, if it is used for a prolonged period, it is capable of causing dose-related hepatocellular toxicity. Toxic doses of Paracetamol can cause hepatotoxicity-related fluid retention (weight gain) or alteration in haematological profiles in humans and animals. The ill effects of modern drugs on human beings and the expense for their treatment have certainly highlighted the need for research into herbal drugs. The theory of Paracetamol effect on the liver can be compared with the concept of dushi visha. Bilwadi agad is a frequently used medicine in different conditions like venomous snake bites, insect bites and scorpion stings in the state of Kerala. Most of the contents of Bilwadi agad have antioxidant properties and they act on Liver and Kidneys as well, according to Ayurveda. All these facts demand for the research to find out a safe, cost-effective and efficient Ayurvedic formulation to treat the Paracetamol-induced haematological changes and observe its effects on internal organs. The current study aims to develop a new standard herbal formulation with its in-vivo study to screen its effectiveness in Swiss albino mice. The obtain results and conspicuous observation have been discuss with scientific reasoning. Effect of antidote Churna was previously studied by researcher, its further step to observe its effects on Haematological Profiles and Body Weight.