HOST GENE POLYMORPHISM INCREASING SUSCEPTIBILITY TO TUBERCULOSIS AMONG PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

Back ground: Tuberculosis (TB) is a major health problem globally. Immune dysfunction is found to be associated with the increased incidence of TB. Immune dysfunction in diabetes mellitus (DM) increases the risk of developing active TB. Host genetic factors were described to be one of the possible risk factors for TB susceptibility. This study aimed to look for FOKI polymorphism of Vitamin D receptor and the polymorphism of Solute Carrier Family 11 member 1 (SLC11A1) genes 3’UTR, D543N and INT4. Method: This was a prospective case-control study. Patients with type 2 DM and TB were recruited as cases and patients with type 2 DM without TB as controls. The host gene polymorphism was determined using PCR-RFLP. Result: Among the SLC11A1 genes tested, the TG/TG +/- heterozygous allele of 3’UTR and the G/G homozygous wild type allele of D543N varied significantly between the patients with DM andTB when compared with the patients with control arm. FOKI polymorphism of the vitamin D receptor and the INT4 polymorphism of SLC11A1 did not vary between cases and controls. Conclusion: The allelic forms of 3’UTR and D543N of SLC11A1 genes were found to be significantly associated with TB among patients with type 2 DM.