SYSTEMS-LEVEL ENGINEERING STRATEGIES FOR IMPROVING EFFICIENCY AND STABILITY IN BIO-BASED PRODUCTION PLATFORMS

Abstract

Background: The bio-based production platforms have gained significance in sustainable manufacturing due to the possibility of producing biofuels, pharmaceuticals and biochemicals out of renewable resources. Nevertheless, high efficiency and stability in these systems is still a major issue because of the metabolic constraints as well as variability in the environment.

Objective: The aim of the present study is to assess systems-level engineering techniques to enhance efficiency and stability of bio-based manufacturing platforms.

Methodology: In-depth literature review on the topics of recent research in systems biology, metabolic engineering and process integration was carried out. Experimental and computational data were examined to evaluate how pathway optimization and regulation and integrated bioprocess strategies affect system performance.

Results: The yield of products in terms of yield showed an improvement of 25-60% using systems-level approaches and also led to increased stability during production cycles through decreased genetic and metabolic variability. Combination of multi-omics data and strategies of process control enhanced resource allocation and optimization of the system.

Conclusion: Engineering systems-level can play a crucial role in improving the performance and reliability of bio-based production platforms. The combination of biological, computational and process engineering methodologies is vital towards scalable, steady and long-term bioproduction.