ASSOCIATION BETWEEN TIMI SCORE (THROMBOLYSIS IN MYOCARDIAL INFARCTION) WITH TROPONIN I & EJECTION FRACTION IN ACUTE ST SEGMENT ELEVATION MYOCARDIAL INFARCTION

Abstract

Acute ST-segment elevation myocardial infarction (STEMI) represents a severe form of coronary artery disease that demands rapid and accurate risk assessment to guide management. The TIMI (Thrombolysis in Myocardial Infarction) risk score, cardiac Troponin I levels, and left ventricular ejection fraction (EF) are well-established prognostic indicators; however, their combined relationship in STEMI patients remains inadequately defined. Aim & Objective: This study aimed to evaluate the association between TIMI risk score, Troponin I levels, and ejection fraction in patients presenting with acute STEMI. It further sought to analyze their correlations, assess interrelationships, and determine their combined predictive value for risk stratification. Materials & Methods: A cross-sectional study was conducted among 94 patients diagnosed with STEMI at Sree Balaji Medical College and Hospital, Chennai. TIMI scores were calculated at admission, and patients were stratified into low-risk (0–4), intermediate-risk (5–9), and high-risk (≥10) categories. Serum Troponin I levels were measured, and left ventricular ejection fraction was assessed using echocardiography. Statistical analysis included Pearson correlation, linear and logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: A significant positive correlation was observed between TIMI score and Troponin I levels (r = 0.64, p < 0.001), whereas TIMI score showed a significant negative correlation with ejection fraction (r = −0.56, p < 0.001). Both Troponin I and EF emerged as independent predictors of high TIMI risk (OR = 1.788, p = 0.006; OR = 0.65, p < 0.001). The combined predictive model demonstrated excellent diagnostic performance with an AUC of 0.96. Conclusion: TIMI score is significantly associated with Troponin I levels and ejection fraction in STEMI patients. Their combined assessment improves risk stratification and supports more informed clinical decision-making.