PEDIATRIC CHRONIC MYELOID LEUKEMIA: UNRAVELING DIVERSE PRESENTATIONS AND MANAGEMENT CHALLENGES IN TWO CASES

Abstract

This article presents two pediatric cases exemplifying the rarity and complexity of Chronic Myeloid Leukemia (CML) among pediatric population. First patient is a 13-year-old, exhibited classic CML manifestations, including hyper-leukocytosis, hepatosplenomegaly, and molecular confirmation of the BCR-ABL fusion gene. The second patient is an 8-year-old, demonstrated an unusual presentation with dual Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (ALL) and CML in blast phase. Comprehensive investigations, including bone marrow aspiration, flow cytometry, and molecular studies, played a main role in confirming diagnoses, tracking disease progression, and tailoring treatment. These cases highlight the critical role of a multifaceted diagnostic approach in pediatric CML, emphasizing the need for good understanding and individualized management.