CLINICAL PRESENTATION AND OUTCOME OF PATIENTS PRESENTING WITH ACUTE ORGANOPHOSPHORUS POISONING IN EMERGENCY DEPARTMENT OF LADY READING HOSPITAL PESHAWAR

Abstract

Objective: To determine the clinical presentation and outcome of patients presenting with acute organophosphorus poisoning in the Emergency Department of Lady Reading Hospital Peshawar. Methods: This cross sectional study was conducted in the Department of General Medicine and Emergency Department of Lady Reading Hospital Peshawar from 15 July 2025 to 15 November 2025. A total of 139 patients with acute organophosphorus poisoning were enrolled through consecutive nonprobability sampling. Demographic characteristics clinical manifestations and outcomes were recorded using a structured proforma. Clinical presentations including bronchospasm urination miosis salivation and lacrimation were assessed. Data were analyzed using Statistical Package for Social Sciences version 27 and a p value of less than 0.05 was considered statistically significant. Results: The mean age of the patients was 31.8 ± 11.6 years and 84 patients were male. Deliberate self poisoning was observed in 72.7 percent of cases. Miosis was the most common clinical manifestation and was present in 97.8 percent of patients followed by salivation in 84.9 percent lacrimation in 70.5 percent bronchospasm in 69.1 percent and urinary manifestations in 58.3 percent. Recovery was achieved in 125 patients whereas 14 patients expired giving a mortality rate of 10.1 percent. Bronchospasm showed a significant association with mortality. Conclusion: Acute organophosphorus poisoning was associated with a high frequency of cholinergic manifestations and considerable mortality. Early recognition and prompt management may improve clinical outcomes and reduce fatal complications.