ADIPOCYTOKINES IN OBESE AND NON-OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME

Abstract

Aims and Objectives: Dysregulation of adipocytokines play a key role in the pathogenesis of polycystic ovary syndrome (PCOS). This study aimed to compare serum adiponectin, osteocalcin and resistin levels in obese PCOS (BMI≥25kg/m2) and non-obese PCOS (BMI<25kg/m2) subjects and then to compare with their age and BMI matched controls. Materials and methods: A total number of 81 PCOS subjects (Obese-42; Non-obese-39) and controls (Obese 42; Non obese-44) were recruited in the study. A Rotterdam criterion was used for the diagnosis of PCOS. All patients underwent detailed clinical, anthropometric, hormonal assessment, insulin resistance indices and serum levels of adipocytokines (adiponectin, resistin and osteocalcin). Results: Forty five percent of overall PCOS subjects (obese PCOS: 60% and non-obese PCOS: 30%) had features of either clinical or biochemical evidence of hyperandrogenism. Serum adiponectin levels were significantly (p<0.05) lower in subjects with obese PCOS (4.3 ± 2.0 mcg/ml) when compared to its controls (5.5 ± 2.8 mcg/ml). Serum osteocalcin levels were significantly lower (p<0.005) in non-obese PCOS subjects (14.4 ± 7.2 ng/ml) when compared to age and BMI matched controls (19.7 ± 8.4 ng/ml). Serum resistin was not significant in both the groups. Serum adiponectin levels were significantly lower (p=0.02) and serum resistin levels were significantly higher (p=0.02) in obese PCOS when compared to non-obese PCOS. Serum adiponectin and osteocalcin had significant negative spearman’s correlation with free testosterone index. Serum osteocalcin and adiponectin had a significant positive correlation (p<0.05) with quantitative insulin sensitivity check index (QUICKI) whereas serum resistin had a significant negative correlation (p=0.03) with QUICKI. Conclusion: Significant derangements in serum adipocytokines levels were noticed among the PCOS subjects. Significantly lower serum adiponectin levels in obese PCOS and significantly lower serum osteocalcin levels in non-obese PCOS were noticed when compared to their age and BMI matched controls. Serum resistin levels were not significantly different. Significantly lower serum adiponectin levels and higher resistin levels were noticed in women with obese PCOS when compared to non-obese PCOS.