INVESTIGATING THE IMPACT OF ROSUVASTATIN ON LIVER FUNCTION BY ASSESSING BIOMARKERS RELATED TO LIVER SYNTHESIS AND EXCRETION IN PATIENTS WITH CARDIOVASCULAR ATHEROSCLEROSIS

Abstract

Background: Rosuvastatin serve as a fundamental treatment for lowering the level of LPL-cholesterol, helping to prevent the risk of atherosclerosis cardiovascular disease that leads to death. This makes Rosuvastatin among the most widely prescribed medication classes globally. The liver-related side effects of Rosuvastatin are commonly characterized as an elevated risk of declining liver function that correlates with higher medication doses. Research indicates that Rosuvastatin -induced liver toxicity usually develops during the initial year of therapy. Objective: To assessment the connection of Rosuvastatin treatment period on liver function activity in people diagnosed with atherosclerotic cardiovascular disease. Method: The research spanned 24 weeks, with monitoring visits scheduled at weeks 1, 8, 16, and 24 to track changes in liver function parameters. The evaluation process incorporated clinical assessments and laboratory testing. To ensure reliable and consistent results, the study maintained rigorous protocols and assigned a dedicated technician to perform all evaluations. Results: Six months following the start therapy with rosuvastatin in atherosclerotic patients result showed: significantly increase (p<0.001) with (ALT, AST, GGT), as a liver injury signs, and result showed as synthetic liver efficacy a relatively significant decrease (p<0.001) in: (Total protein (6.3, 6.2, 5.5, 4.6gm/dL), Albumin (4.2, 3.2, 3.0, 2.8gm/dL), Cholinesterase (10.6, 6.9, 6.5, 4.2 U/L), Prothrombin time showed a significant increase (9.6, 12, 12.8, 13.2) at the period (1,8, 16, and 24 weeks) respectively. Result also showed a significant increase in: Total Bilirubin (0.7, 1.9, 2.5, 3.2 mg/dL), Direct Bilirubin (0.2, 1.2, 1.8, 2.3 mg/dL), ALP (70, 86, 139, 142 U/L), as liver excretion efficacy. Rosuvastatin can cause a variety of changes in the mechanisms of liver function, but not real damage to liver cells and tissues. Although the exact mechanism is still unclear, it is likely related to an idiosyncratic drug-induced liver injury.