A RESEARCH STUDY OF DETERMINING ADAPTABILITY OF MEDICATION ITS FACTORS AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE, A PROSPECTIVE ANALYSIS HOW GUT MICROBIOME AFFECT TREATMENT CYCLE AND QUALITY OF LIFE OF PATIENTS

Abstract

Objective: The objectives of the research were to assess the degree of medication compliance, Microbial factor socio-demographic and clinical variables that influence compliance, and how the compliance and patient psychiatry and gut microbe influences the quality of life related to health in patients with chronic kidney disease. Study Design: A cross-sectional study that is hospital based. Location and Time of the Research: This was done in the Department of Nephrology, Ghurki Trust Teaching Hospital Lahore, THQ Punjab, Pakistan, between September 2025 and January 2026. Methods: There was convenient sampling to recruit 300 patients in stages three to five of chronic kidney disease that were between the ages of eighteen years and above and who had an at least six months history of therapy. The structured questionnaire was used to collect data in terms of socio-demographic and clinical characteristics, the General Medication Adherence Scale, and the Euro Qol Five-Dimension Five-Level Scale. To summarize the data, descriptive statistics were used. The chi-square test was used to test the relationships between adherence and independent variables. Correlation Spearman was used to establish the relationship between medication adherence and health-related quality of life. The binary logistic regression analysis determined independent predictors of non-adherence. The statistical significance was determined as p < 0.05. Results: Out of the three hundred participants, 52.3 percent of participants were found to have good medication adherence whereas 47.7 percent were found to have poor to moderate medication adherence. The greatest inhibitor to compliance was financial burden. Geriatric patients managing CKD often contend with polypharmacy, cognitive decline, and mood disturbance simultaneously, Emerging evidence suggests that CKD-associated gut dysbiosis may influence medication response, systemic inflammation, and neuropsychiatric status through microbial metabolites and the gut–brain axis. yet the combined effect of psychiatric comorbidity on adherence in this population remains insufficiently characterized in nursing literature. Adherence was significantly connected with age, education, income, stage of disease, State of mind of patient, even gut microbe environment and duration of disease and comorbidities. Lack of adherence was largely linked to low health-related quality of life. Conclusion: Almost half of the patients were found to have suboptimal medication adherence. Dividing factors were financial burden, severity of the disease and complexity of treatment. Inadequate compliance was related to decreased quality of life in regard to health implications.