SERUM LIPID PROFILE AND ITS CORRELATION WITH HBA1C AMONG ADULTS TYPE 2 DIABETES MELLITUS PATIENTS - A FACILITY BASED OBSERVATIONAL STUDY

Abstract

Introduction: In Type 2 Diabetes Mellitus(T2DM), chronic hyperglycemia results in nephropathy detectable as rising values of creatinine and decreased levels of eGFR. Objective: To determine the correlation of HbA1c with serum creatinine and estimated glomerular filtration rate among adult patients with type 2 diabetes mellitus. Methods: A facility-based cross-sectional study was carried out on 150 subjects from April 2025 to July 2025 who visited the Diabetes Care Clinic of KLE Dr Prabhakar Kore Hospital & MRC, Belagavi, Karnataka, India. Glycosylated Hemoglobin (HbA1c) and Creatinine levels were measured in T2DM-diagnosed patients. Estimated GFR was calculated using a standard equation. Results: The mean age of the participants was 49.07±9.92 years, with a male prevalence. The mean HbA1c levels of the participants were 8.69±2.33%. A significant correlation was observed between creatinine and eGFR in the study (P<0.05). A non-significant correlation was observed between HbA1c levels and creatinine/eGFR (P>0.05). Conclusion: There was no correlation between HbA1c and either creatinine or eGFR. However, the validated inverse relationship between creatinine and eGFR implies that mechanisms other than chronic hyperglycemia are likely responsible for early renal dysfunction in these patients. Further studies should investigate other risk factors for early renal dysfunction in T2DM patients with poor glycemic control.