COMPARATIVE EVALUATION OF THE TREATMENT OUTCOMES FOR INTRABONY VERTICAL DEFECTS BY USING INTRA ORAL OSSEOUS AUTOGRAFT, DEMINERALIZED BONE MATRIX ALONE AND A COMBINATION OF DEMINERALIZED BONE MATRIX AND INJECTABLE PLATELET RICH FIBRIN - A CLINICAL AND

Abstract

Background: Periodontal intrabony defects are a major problem to treat in periodontology, making regenerative therapy necessary to obtain a desired clinical outcome. Alternatives to autogenous bone grafts (ABG) used to improve periodontal regeneration include demineralized bone matrix (DBM) and platelet rich fibrin (PRF) injected (i-PRF). Study Design: The study was a randomized, single blind, parallel arm clinical study that compared the efficacy of ABG, DMBM and DMBM + i-PRF for the treatment of periodontal intrabony defects. Materials and Methods: The study subjects were 45 patients with chronically diseased periodontal tissues, who had intrabony defects and were randomly divided into three groups: (A) ABG, (B) DMBM and (C) DMBM + i-PRF (15 patients in each group). “Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Relative Clinical Attachment Level (RCAL) were measured at baseline, 3 months and 6 months. Baseline and 6 months, radiographs were used to assess residual bone level. Statistical Analysis: Data were analyzed using Repeated Measures ANOVA for intragroup comparisons and One-way ANOVA with Tukey’s post hoc test for intergroup comparisons. Statistical significance was set at p < 0.05. Results: All groups demonstrated significant improvements in PPD, RCAL, and residual bone levels from baseline to 6 months (p < 0.001). Significant reductions in PI, GI, and BOP were also observed. Intergroup analysis revealed significantly greater RCAL gain and bone fill in the ABG group compared with the DMBM and DMBM + i-PRF groups (p < 0.05). No significant differences were observed between DMBM and DMBM + i-PRF. Conclusion: All treatment modalities were effective in improving periodontal parameters; however, ABG demonstrated superior regenerative outcomes compared with DMBM alone or DMBM combined with i-PRF.