Gene–Environment Interplay in Psychiatric Risk as a Framework for Clinical Psychology
DOI:
https://doi.org/10.4238/77z68g94Abstract
Psychiatric disorders are complex conditions influenced by both genetic and environmental factors. Gene–environment interplay-including gene–environment correlations (rGE) and gene–environment interactions (G×E)-offers a framework for understanding individual variability in susceptibility, resilience, and risk. rGE processes highlight how genotypes influence exposure to environmental conditions, whereas G×E emphasizes how environmental contexts shape the expression of genetic predispositions. Transactional and dynamic models further capture how genetic susceptibility and environmental selection interact iteratively across development. Integrating genomic, environmental, and longitudinal data enhances risk prediction and informs precision approaches in clinical assessment and intervention. This framework underscores the potential of gene–environment research to refine preventive and therapeutic strategies in psychiatry.
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Copyright (c) 2026 Nigina Mukhamadiyeva, Nodirbek Ashrapov, Bobir Turaev, Uktamxon Axmedova, Surayyo Kurbanova, Akhrarkul Pardaev, Kholbek Shermatov (Author)

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

