Gene–Environment Interplay in Psychiatric Risk as a Framework for Clinical Psychology

Authors

  • Nigina Mukhamadiyeva Author
  • Nodirbek Ashrapov Author
  • Bobir Turaev Author
  • Uktamxon Axmedova Author
  • Surayyo Kurbanova Author
  • Akhrarkul Pardaev Author
  • Kholbek Shermatov Author

DOI:

https://doi.org/10.4238/77z68g94

Abstract

Psychiatric disorders are complex conditions influenced by both genetic and environmental factors. Gene–environment interplay-including gene–environment correlations (rGE) and gene–environment interactions (G×E)-offers a framework for understanding individual variability in susceptibility, resilience, and risk. rGE processes highlight how genotypes influence exposure to environmental conditions, whereas G×E emphasizes how environmental contexts shape the expression of genetic predispositions. Transactional and dynamic models further capture how genetic susceptibility and environmental selection interact iteratively across development. Integrating genomic, environmental, and longitudinal data enhances risk prediction and informs precision approaches in clinical assessment and intervention. This framework underscores the potential of gene–environment research to refine preventive and therapeutic strategies in psychiatry.

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Published

2026-01-06

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Section

Articles

How to Cite

Gene–Environment Interplay in Psychiatric Risk as a Framework for Clinical Psychology. (2026). Genetics and Molecular Research, 25(1). https://doi.org/10.4238/77z68g94