FORMULATION DEVELOPMENT, OPTIMIZATION AND PHARMACOKINETIC EVALUATION OF PRAZIQUANTEL LOADED SOLID SELF EMULSIFYING DRUG DELIVERY SYSTEM

Authors

  • Dr. Kiran C. Mahajan Author
  • Dr. Vivek S. Tarate Author
  • Dr. Ashwini N. Devhadrao Author
  • Dr. Nitin V. Devhadrao Author
  • Dr. Shilpa S. Kolhe Author
  • Dr. Sagar A. Jadhav Author
  • Dr. Priyanka S. Chaudhari Author

DOI:

https://doi.org/10.4238/f58wm961

Keywords:

Praziquantel, S-SEDDS, Pharmacokinetic Analysis, Distoside Tablet, Similarity Factor

Abstract

The current study was aimed to develop and optimize a solid self emulsifying drug delivery system for pediatric patients to improve the oral bioavailability and solubility of the anthelmintic drug, Praziquantel (PZQ). The optimized S-SEDDS tablet T3 batch showed minimum disintegration time and maximum drug release. In vivo pharmacokinetic activity in rats revealed that optimized S-SEDDS tablets (T3) had 2.14 folds higher bioavailability than marketed PZQ tablet and it produces rapid onset of action. The peak drug concentration (Cmax) of optimized S-SEDDS tablet T3 batch was approximately 1.76 fold higher than marketed tablet.

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Published

2026-07-07

Issue

Vol. 25 No. 10s (2026)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.