FORMULATION AND EVALUATION OF VILDAFORMIN TABLET SMEDDS

Abstract

Potential lipid-based formulations that are designed to dissolve a poorly aqueous-soluble drug include self-microemulsifying drug delivery systems (SMEDDS). Vildaformin, a complex of Vildagliptin and Metformin, is correlated with dissolution and solubility issues that affect therapeutic effect. In the present study, the solid SMEDDS (S-SMEDDS) was prepared by dissolving Vildaformin in a liquid SMEDDS formulation composition of Tween 80 (Surfactant), Propylene glycol (Co-surfactant), and White Sesame oil (Oil phase) and adsorbed onto Aerosil 200. Optimized formulation was pressed into tablets with excipients of preference, and evaluated for micromeritics, morphology, thermal and structural properties using Carr index and Hausner ratio, SEM, PXRD, and DSC. The hardness, weight variation, friability, and disintegration of the tablets were satisfactory. The improved solubility and dissolution characteristics were demonstrated by an in-vitro dissolution study that found drug dissolution in T-SMEDDS tablets much greater than drug dissolution in pure drug and marketed tablet. The findings suggest that the tablet formulation of T-SMEDDS should be considered as a potential solution to increase oral bioavailability and adherence to Vildaformin owing to the enhanced dissolution and absorption.