ENHANCEMENT OF IBUPROFEN’S PHYSICOCHEMICAL PROPERTIES BY DEVELOPING ITS COCRYSTALS

Abstract

Pharmaceutical cocrystals, which are formed when an active pharmaceutical ingredient (API) and a pharmaceutically acceptable coformer interact noncovalently, have become a popular method for improving the physicochemical characteristics of drug moiety without alter pharmacological activity. For the selection of the drug and coformer , the ∆pKa technique and CSD software were employed. The Cocrystals were prepared using the solvent evaporation method and their characterization was performed using DSC, XRD and FTIR techniques. In vivo anti-inflammatory activity was evaluated using 24 Wistar rats. In the present study, in vitro dissolution studies revealed increased solubility profile for the cocrystals when compared with the pure drug and a marketed formulation. Furthermore, the cocrystals demonstrated enhanced in vivo anti-inflammatory potentials compared to reference drug. The results of this research revealed that the  physicochemical properties of BCS class II APIs can be significantly improved without altering or affecting their therapeutic efficacy.