ASSOCIATION OF IFNL4, IL10, IL-6 GENE POLYMORPHISM AND COVID VIRAL DISEASES: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract

The SARS-CoV-2 virus caused the respiratory illness known as coronavirus disease 2019 (COVID-19) in 2019 (Lai et al., 2020).The global outbreak of COVID-19, starting in Wuhan, China, affected countries worldwide. The condition might cause mild sickness or even death in certain people (Mohan & Nambiar, 2020; Manzoor et al,2026).Blood clotting abnormalities, linked to elevated D-dimer and fibrinogen, play a significant role in COVID-19 severity (Eljilany & Elzouki, 2020).Despite over 275 million confirmed cases worldwide, the actual number of infections is estimated to be much higher. Many individuals may have contracted COVID-19 without symptoms or hospitalization. It is possible that many genes and genetic variations enhance the risk of severe COVID-19 (Choudhary et al., 2021; Moneshwaran et al,2024).