CHARACTERIZATION OF MANGO SEED AQUEOUS EXTRACT AND ITS ADJUNCTIVE THERAPEUTIC EFFECTS IN GASTRIC ULCER

Abstract

M. indica L. seed is a by-product of the mango yield that is abundant and rich in bioactive compounds that may be used in therapeutic applications. The purpose of this study was to characterize the aqueous extract of mango seed and assess its gastroprotective action in patients suffering from gastric ulcers in a randomized controlled clinical trial. There were 60 patients in total, with half of them in the control group and the other half in the intervention group. The groups were given standard anti-ulcer treatment (omeprazole and clarithromycin) along with a modified diet, but the intervention group was also given mango seed aqueous extract (3g/day) for 12 weeks. Standard methods were used to determine the proximate composition, phytochemicals, and antioxidant activity of the extract. Pre and post-treatment clinical, endoscopic, and histopathological evaluation was done. The extract was found to have a high concentration of carbohydrates, phenolics, flavonoids, tannins, and alkaloids with high antioxidant activity (IC₅₀ = 62.18µg/mL). In the intervention group, ulcer healing was significantly improved (70 vs 30%) with a decrease in ulcer size, symptom scores, and histopathological damage when compared with controls (p < 0.05). Endoscopic examinations also revealed improved mucosal healing. There were no serious adverse effects observed. The results indicate that mango seed aqueous extract has potent antioxidant and gastroprotective activity and can be used as a natural alternative to gastric ulcer treatment in the future without any side effects.