ENHANCEMENT OF ACECLOFENAC’S PHYSICOCHEMICAL PROPERTIES BY DEVELOPING ITS COCRYSTALS

Abstract

The design, development and characterisation of aceclofenac cocrystals is the focus of this study. Co-crystallisation known as key method for improving drug’s solubility in aqueous medium as it modifies crystal structure by co-former incorporation in formulation. In the present work, for co-former and drug selection ∆pKa method as well as CSD software were used. Solvent evaporation method for cocrystal formation was used. Cocrystals were analysed by using XRD, FTIR and DSC methods. Anti-inflammatory activity (in vivo) was performed on Albino Wistar rats. In present study, after comparison of cocrystals with marketed formulations and pure drug dissolution studies (in vitro) demonstrated enhanced solubility profile of cocrystals. In vivo study showed increased anti-inflammatory effects in comparison to standard drug. Based on results of present study we found that co-crystallization improves physicochemical properties of APIs of BCS class II without altering their pharmacological effects.