ASSOCIATION OF HAEMATOLOGICAL PARAMETERS WITH GLYCAEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES – A STUDY

Abstract

This research explores the intricate relationship between red blood cell indices, haemoglobin, and haematocrit in relation to Type 2 Diabetes (T2DM). The research particularly focuses on understanding how these haematological parameters correlate with glycated haemoglobin (HbA1c), an indicator of long-term glycaemic control. A cohort of 50 T2DM patients, aged 45-72 years, was analyzed to assess various red blood indices, including haemoglobin, haematocrit, MCV, MCH, MCHC, and RDW-CV. The findings revealed a significant negative correlation between HbA1c and key parameters such as haemoglobin (-0.42, p=0.005), haematocrit (-0.40, p=0.008), and MCH (-0.45, p=0.003), indicating that lower levels of these factors are linked with poor glycaemic control. Conversely, RDW-CV displayed a strong positive correlation with HbA1c (0.50, p=0.001), suggesting that increased variability in red blood cell size is linked to higher HbA1c levels. Regression analysis confirmed these findings, with haemoglobin (-0.25, p=0.002) and RDW-CV (0.33, p<0.001) emerging as significant predictors of HbA1c levels. These findings highlight the critical role that haematological factors play in the metabolic profile of T2DM patients. Integrating red blood indices with HbA1c assessments can offer deeper insights into diabetes management, providing a more comprehensive understanding of disease complications like cardiovascular and kidney dysfunction. This study underscores the potential of using these parameters to enhance therapeutic strategies for improved outcomes in T2DM care.