MOLECULAR GENETIC MARKERS OF INFLAMMATION IN CARDIOVASCULAR PATHOLOGY

Abstract

The article summarizes modern ideas about the role of inflammation and immunomodulation in the pathogenesis of cardiovascular diseases, with an emphasis on the mechanisms of vascular wall and myocardial remodeling. Based on the analysis of domestic and foreign studies in recent years, the involvement of innate and adaptive immunity, key cytokines and inflammatory biomarkers in the development of atherosclerosis, coronary artery disease and heart failure has been considered. Special attention is paid to the diagnostic and prognostic significance of markers of systemic inflammation, as well as the possibilities of their integration into clinical practice. It has been shown that immunomodulatory therapeutic strategies go beyond the traditional lipid-lowering approach and open up prospects for targeted effects on the pathogenetic links of the disease. The presented data emphasize the scientific and clinical significance of an integrated approach to assessing the inflammatory status of a patient in the context of personalized cardiology.