COMPARISON OF AN INDUCTION MODELS FOR THE DEVELOPMENT OF PSYCHOSIS CONDITION AND ITS ASSESSMENT TARGETING D2 RECEPTORS BY PRECLINICAL STUDIES

Abstract

Preclinical animal models are essential for elucidating the neurobiological mechanisms underlying
psychosis, stress-related psychopathology and for evaluating potential therapeutic agents. Among the various experimental paradigms, Chronic Unpredictable Mild Stress (CUMS), Olfactory Bulbectomy (OBX) and Dexamethasone-induced glucocorticoid exposure model are widely employed in rats to behavioural, neuroendocrine, and neurochemical alterations relevant to depressive-like states leading to cause depression induced psychosis. The behavioural parameters such as hyperactivity, stereotypy, etc., biochemical estimation such as dopamine, lipid peroxidation and histopathological studies were studied. It was concluded that among all the three models of induction- olfactory bulbectomy induces psychosis model had shown the good result.