R. Rahimnia, S.M. Rezayat, R. Torabi, H. Soltanghoraee, B. Mehravi, A. Amani, S. Kharrazi, M. Amanlou
Published: November 12, 2018
Genet. Mol. Res. 17(4): GMR18037
DOI: https://doi.org/10.4238/gmr18037
Cite this Article:
R. Rahimnia, S.M. Rezayat, R. Torabi, H. Soltanghoraee, B. Mehravi, A. Amani, S. Kharrazi, M. Amanlou (2018). Gold nanoparticle sucrose complexes as potent anti-inflammatory agents. Genet. Mol. Res. 17(4): GMR18037. https://doi.org/10.4238/gmr18037
About the Authors
R. Rahimnia, S.M. Rezayat, R. Torabi, H. Soltanghoraee, B. Mehravi, A. Amani, S. Kharrazi, M. Amanlou
Corresponding Author
M. Amanlou
Email: amanlou@tums.ac.ir
ABSTRACT
Gold nanoparticles (GNPs) with controlled geometric properties are new options for the management of inflammatory responses and therapy for various diseases, including diabetes mellitus, rheumatoid arthritis, and connective tissue diseases. We examined anti-inflammatory impacts of sugar coated GNPs with different sizes on carrageenan-induced rat paw inflammation. The synthesized GNPs were compared with indomethacin, methotrexate and the commercial gold preparation myochrysine. While methotrexate and myochrysine did not have any significant effects on rat paws, GNPs significantly decreased the inflammatory responses, comparable with indomethacin, a standard anti-inflammatory drug in the rat paw model. There was no harmful effect on metabolic activity of cells treated with GNPs of different sizes. We conclude that sugar coated GNPs are a promising candidate for new options in the management of inflammatory-related diseases.
Key words: Anti-Inflammatory agent, Carrageenan, Gold nanoparticles, Toxicity.