V. D’Afonseca, P.M. Moraes, F.A. Dorella, L.G.C. Pacheco, R. Meyer, R.W. Portela, A. Miyoshi, V. Azevedo
Published: March 18, 2008
Genet. Mol. Res. 7 (1) : 252-260
DOI: https://doi.org/10.4238/vol7-1gmr438

Cite this Article:
V. D’Afonseca, P.M. Moraes, F.A. Dorella, L.G.C. Pacheco, R. Meyer, R.W. Portela, A. Miyoshi, V. Azevedo (2008). A description of genes of Corynebacterium pseudotuberculosis useful in diagnostics , and vaccine applications. Genet. Mol. Res. 7(1): 252-260. https://doi.org/10.4238/vol7-1gmr438

About the Authors
V. D’Afonseca, P.M. Moraes, F.A. Dorella, L.G.C. Pacheco, R. Meyer, R.W. Portela, A. Miyoshi, V. Azevedo

Corresponding author
V. Azevedo
E-mail: vasco@icb.ufmg.br

ABSTRACT

Corynebacterium pseudotuberculosis, a Gram-positive intracellular pathogen, is the etiological agent of caseous lymphadenitis or CLA. This bacterium infects goats and sheep and causes great economic losses worldwide annually, mainly for goat producers. Despite its importance, CLA is still poorly characterized. However, with advances in the genomic field, many C. pseudotuberculosis genes have already been characterized, mainly those related to virulence such as phospholipase D. Here, we examined the use of the several available genes of C. pseudotuberculosis and reviewed their applications in vaccine construction, more efficient diagnostics for CLA, and control of this disease, among other applications

Key words: Phospholipase D, RecA, Caseous lymphadenitis.